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Clin Transplant ; 35(2): e14169, 2021 02.
Article in English | MEDLINE | ID: covidwho-947755

ABSTRACT

Transplant recipients are vulnerable to infections, including COVID-19, given their comorbidities and chronic immunosuppression. In this study, all hospitalized renal transplant recipients (RTR) with a positive nasal swab for Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV2) seen consecutively between 03/01/2020 and 05/01/2020 at the Detroit Medical Center were included. Data on demographics, clinical presentation, laboratory findings, management, and outcomes were collected. Twenty-five patients were included, all African American (AA) and deceased-donor transplant recipients. The most common presenting symptom was dyspnea, followed by fever, cough and diarrhea. Multifocal opacities on initial chest x-ray were seen in 52% patients and 44% of patients had a presenting oxygen saturation of less than or equal to 94%. Four patients (16%) required transfer to the intensive care unit, one required intubation and one expired. COVID-19-infected RTR in this cohort had low mortality of 4% (n = 1). Despite multiple comorbidities and chronic immunosuppression, our cohort of African American RTR had favorable outcomes compared to other reports on COVID-19 in RTR.


Subject(s)
Black or African American , COVID-19/ethnology , Immunosuppression Therapy/methods , Intensive Care Units , Kidney Transplantation , Liver Failure/ethnology , Transplant Recipients , Aged , Comorbidity , Female , Humans , Liver Failure/surgery , Male , Michigan/epidemiology , Middle Aged , RNA, Viral/analysis , SARS-CoV-2/genetics
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